Haiyen E. Zhau, Ph.D.
Associate
Professor
Molecular Urology and Therapeutics Program
Department of Urology
Contact Information
Department of Urology
Emory University School of Medicine
Clinic B, Suite 5107
1365 Clifton Road, N.E.
Atlanta, GA 30322
Phone: 404-778-4603
Fax: 404-778-3965
Email: hzhau@emory.edu
Education
BS, Tunghai University, Taichung,
Taiwan, 1962-1966, Biology
MS, Boston University, Boston, Massachusetts, 1967-1969, Biochemistry
PhD, McGill University, Montreal, Quebec, Canada, 1973-1977, Biochemistry
Research Interests
Dr. Zhau has developed a program with focus on elucidating the functional role of androgen-receptor during androgen-independent prostate cancer progression. Interaction between androgen-receptor and other transcription factors, such as NF-KB, estrogen receptors, and cytokine mediated signaling cascade are evaluated in aggressive human prostate cancer cell lines. Therapeutic targeting of these various pathways and their implication in reducing prostate cancer colonization in the bone will be especially emphasized.
Selected Publications
Zhau HYE, Zhang X, von Eschenbach AC, Scorsone K, Babaian RJ, Ro JY and Hung MC. Amplication and expression of the c-erb B-2/neu proto-oncogene in human bladder cancer. Mole. Carcinogen. 3:254-257, 1990.
Chung LWK, Hong SJ, Zhau HYE, Camps JL, Chang SM, Freeman MR and Gao C. Fibroblast-mediated human epithelial tumor growth and hormonal responsiveness in vivo. Mole. and Cell. Biol. of Prostate Cancer 91-102, 1991.
Zhau HYE, Wan DS, Zhou JX, Miller GJ, and von Eschenbach AC. Expression of c-erb B2/neu protooncogene in human prostatic cancer tissues and cell lines. Molec Carcinogen. 5:320-7, 1992.
Hsieh JT, Zhau HYE, Wang XH, Liew CC, and Chung LWK. Regulation of basal and luminal cell-specific cytokeratin expression in rat accessory sex organs. J of Biol Chem. 267(4):2303-10, 1992.
Chung LWK, Li W, Gleave ME, Hsieh JT, Wu HC, Sikes RA, Zhau HYE, Bandyk MG, Logothetis CJ, Rubin JS, and von Eschenbach AE. Human prostate cancer model: Roles of growth factors and extracellular matrices. J of Cell Biochem, Suppl. 16H:99-105, 1992.
Chung LWK, Chuan G, Li W, and Zhau HYE. Stromal-epithelial interaction: Implications for prostate tumorigenesis. The Cancer Bulletin. 45:430-5, 1993.
Zhau HYE, Sikes RA, and Chung LWK. The c-erb B-2 oncogene in human prostate cancer growth and progression. CRC Press. 207-20, 1994.
Zhau HYE, Pisters LL, Hall MC, Zhao LS, Troncoso P, Pollack A, and Chung LWK. Biomarkers associated with prostate cancer progression. J of Cell Biochem, Suppl. 19:208-16, 1994.
Thalmann GN, Anezinis PE, Chang S-M, Zhau HYE, Kim E, Hopwood VL, Pathak S, von Eschenbach AE, and Chung LWK. Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res. 54:2577-81, 1994.
Zhau HYE, Hong S-J, and Chung LWK. A fetal rat urogenital sinus mesenchymal cell line (rUGM) accelerated growth and conferral of androgen-induced growth responsiveness to a human bladder cancer epithelial cell line in vivo. Int’l J of Cancer. 56:706-14, 1994.
Hall MC, Troncoso P, Pollack A, Zhau HYE, Zagars GK, Chung LWK, and von Eschenbach AC. Significance of tumor angiogenesis in clinically localized prostate carcinoma treated with external beam radiotherapy. Urol. 44(6):869-75, 1995.
Pisters LL, Troncoso P, Pollack A, Zhau HYE, Li W, von Eschenbach AC, and Chung LWK. c-met proto-oncogene expression in benign and malignant human prostate tissues. J of Urol. 154:293-8, 1995.
Zhau HYE, Zhao L-S, Chung LWK, Chen B-Q, Troncoso P, Kao C, Kojima M, Symmans WF, Zheng N, Palmer JL, Moul JW, Davis R, Ye M-F, Xiao L-S, and Hall MC. Comparative studies of prostate cancers among U.S., Chinese, and Japanese patients: Characterization of histopathology, tumor angiogenesis, neuroendocrine factors, and p53 protein accumulations. Urologic Oncol. 1(2):51-63, 1995.
Chung LWK and Zhau HYE. “The role of stromal-epithelial interaction in the normal and abnormal growth of the prostate”. In Basic Research in Urological Oncology. Ed: Luciani L, Debruyne FMJ, Schalken JA. S. Karger, Basel: Switzerland, pp.16-27, 1996.
Zhau HYE, Zhou J, Symmans WF, Chen B-Q, Chang SM, Sikes RA, and Chung LWK. Transfected neu oncogene induces human prostate cancer metastasis. The Prostate. 28:73-83, 1996.
Ko S-C, Gotoh A, Thalmann GW, Zhau HYE, Johnston DA, Zhang WW, Kao C, and Chung LWK. Molecular therapy with recombinant p53 adenovirus in an androgen-independent metastatic human prostate cancer model. Human Gene Therapy. 7:1683-91, 1996.
Zhau HYE, Chang S-M, Chen B-Q, Wang Y, Zhang H, Kao C, Sang QA, Pathak SJ, and Chung LWK. Androgen-repressed phenotype in human prostate cancer. Proc Nat’l Acad of Sci. 93:15152-7, 1996.
Zhau HYE, Goodwin TJ, Chang S-M, Baker TL, and Chung LWK. Establishment of a 3-dimensional human prostate organoid co-culture under microgravity-simulated conditions: Evaluation of androgen-induced growth and PSA expression. In Vitro Cell Develop Biol. 33:375-80, 1997.
Zhau HYE, Zhao L-S, Chen B-Q, and Kojimas M. Interracial comparative study of prostate cancer in the United States, China, and Japan. J of Cell Biochem, Suppl. 28/29:182-6, 1997.
Chung LWK, Kao C, Sikes RA and Zhau HYE. Human prostate cancer progression models and therapeutic intervention. Acta Urol. Jpn. 815-820, 1997.
Shen J, Zhau HYE, Hursting SD, and Chung LWK. Androgen regulation of the human pseudoautosomal gene MIC2, a potential marker for prostate cancer. Molec Carcinogen. 23:13-9, 1998.
Gardner TA, Ko S-C, Kao C, Shirakawa T, Cheon J, Gotoh A, Wu TT, Sikes RA, Zhau HYE, Cui Q, Balian G, and Chung LWK. Exploiting stromal-epithelial interaction for model development and new strategies of gene therapy for prostate cancer and osteosarcoma metastases. Gene Therapy Molec Biol. 2:41-58, 1998.
Rhee, HW, Chang SM, Zhau HYE, Pathak S, Multani AS, Visakorpi T, Gardner TA, and Chung LWK. Permanent phenotypic and genomic changes of a human prostate cancer cell line LNCaP through cellular interaction with prostate or bone fibroblasts in vivo or under microgravity-simulated growth conditions. Cancer Detect and Prev. 23:13-9, 1998.
Zhau HYE, Li C-L, Yang H, Dong J-T, Visakorpi T, Sipe TW, Frierson H, Wan Y-Z, Wang Y, Sikes R, and Chung LWK. Genotypic comparison of prostate cancers among U.S. whites, U.S. blacks, and Mainland Chinese men. J of Urol. 161(4):266A, 1999.
Zhau HYE, Li C-L, Zhang H, and Chung LWK. A potential flutamide-withdrawal prostate cancer cell model: The growth of ARCaP cells stimulated by flutamide and repressed by flutamide-withdrawal. J of Urol. 161(4):682A, 1999.
Sang QA, Schwartz MA, Hui L, Chung LWK, and Zhau HYE. Targeting matrix metalloproteinases in human prostate cancer. Ann of the NY Acad Sci. 878:538-40, 1999.
Chung LWK and Zhau HYE. “Stromal-epithelial interaction: From bench to bedside”. In Prostate Cancer: Biology, Genetics, and Novel Therapeutics. Ed. Chung LWK, Isaacs WB, and Simons JM. Humana Press, Inc., Totowa, NJ, 2000.
Zhau HYE, Li C-L, and Chung LWK. Establishment of human prostate cancer skeletal metastasis models. Cancer Suppl. 88(12):2995-3001, 2000.
Ye Q, Chung LWK, Cinar B, Li S, and Zhau HYE. Identification of a novel FAS/ER-alpha fusion transcript expressed in human cancer cells. Biochim et Biophys Acta. 1493:373-7, 2000.
Ye Q, Chung LWK, Cinar B, Li S, and Zhau HYE. Identification and characterization of estrogen receptor variants in prostate cancer cell lines. J of Steroid Biochem and Molec Biol. 75(1):21-31, 2000.
Koeneman KS, Kao C, Ko S-C, Yang L, Wada Y, Kallmes DA, Gillenwater JY, Zhau HYE, Chung LWK, and Gardner TA. Osteocalcin directed gene therapy for prostate cancer bone metastasis. World J of Urol. 18:102-10, 2000.
Edlund M, MiyamotoT, Sikes RA, Ogle R, Laurie GW, Farach-Carson MC, Otey CA, Zhau HYE, and Chung LWK. Integrin expression and utilization by LNCaP prostate cancer cells on laminin substrata. Cell Growth and Differen. 12:99-107, 2001.
Ye Q, Cinar B, Edlund M, Chung LWK and Zhau HYE. Inhibition of growth and cell cycle arrest of ARCaP human prostate cancer cells by ectopic expression of ER-alpha. Mol. Cell. Biochem. 228:105-10, 2001.
Cinar B, Koeneman K, Edlund M, Prins GS, Zhau HYE, and Chung LWK. Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene rransactivation in a human prostate cancer cell line. Cancer Res. 61:7310-7, 2001.
Tang S, Bhatia B, Maldonado CJ, Yang P, Newman RA, Liu J, Chandra D, Traag J, Klein RD, Fischer SM, Chopra D, Shen J, Zhau HYE, Chung LWK and Tang DG. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. J. Biol. Chem. 277(18):16189-201, 2002.
Hsieh CL, Yang L, Miao L, Yeung F, Kao C, Yang H, Zhau HYE and Chung LWK. A novel targeting modality to enhance adenoviral replication by vitamin D3) in androgen-independent human prostate cancer cells and tumors. Cancer Res. 62(11):3084-92, 2002.
Kubo H, Gardner TA, Wada Y, Koeneman KS, Gotoh A, Yang L, Kao C, Lim SD, Amin MB, Yang H, Black ME, Matsubara S, Nakagawa M, Gillenwater JY, Zhau HYE, and Chung LWK. Phase I Dose-Escalation Clinical Trial of Osteocalcin Promoter-Driven Herpes Simplex Virus Thymidine Kinase Adenovirus in Localized and Metastatic Hormone Refractory Prostate Cancer. Human Gene Therapy 14:227-241, 2003.
Zhao YG, Xiao AZ, Newcomer RG, Park HI, Kang T, Chung LW, Swanson MG, Zhau HYE, Kurhanewicz J, and Sang, QXA. Activation of pro-gelatinase B by endomatase/matrilysin-2 promotes invasion of human prostate cancer cells. J. Biol. Chem. Feb. 13, 2003.