Prostate Cancer Foundation

University of British Columbia Prostate Centre

Emory University Lab

Harvard University Dana Farber Cancer Institute

Bristol-Myers Squibb

Bioinformatics and Biostatistics

MPPP People

Contacts

The Models Predicting Prostate Cancer Progression (MPPP) group is composed of three major components, plus a reference lab. Its goal is to pursue the establishment of reliable and predictive human PCa cell and xenograft models mimicking human PCa progression.

Leaders of four areas of research emphasis are identified:

• Establishment of freshly harvested human PCa xenografts with propensity for bone and soft tissue metastases (YZ Wang and Martin Gleave)
• Provision of well characterized LNCaP and ARCaP progression models and adult, fetal, and reactive stromal cells, and genetically tagged or modified human PCa and stromal cells for further characterization (Leland Chung)
• Provision of immortalized and transformed human prostate epithelial cells, genetically modified cells with defined alterations of cell signaling axis (William Hahn)
• Reference lab at Bristol-Myer where new pharmaceuticals with defined interruption of intracellular signaling network will be tested (Ricardo Attar)

For more information, please contact the investigator by email or call (404) 778-4319.